The 21-year-old finished sixth with a time of 22.24 seconds, trailing only American Gabrielle Thomas, who won in 21.83 seconds.
With a time of 22.08 seconds, Julien Alfred of Saint Lucia won the silver medal, and Brittany Brown of the USA finished third.
Dina Asher-Smith and Daryll Neita of Great Britain placed fourth and fifth, respectively, in the competition.
Despite having the third-best time overall in the semi-finals, Ofili was outmatched by her fellow finalists and did not make it to the final.
She made history by being the first Nigerian to compete in the games’ event final since Mary Onyali done so in Atlanta in 1996.
She made history by being the first Nigerian to compete in the games’ event final since Mary Onyali done so in Atlanta in 1996.
However, Ofili was beaten in the duel. She started the race quickly after the gun, but as the final 100 meters approached, she lost ground.
Her attention will now be on the women’s 4×100 relay, which is scheduled to start on Thursday.